The purpose of this research was to formulate and evaluate bioadhesive buccal tablets of Lesinurad using sodium alginate, sodium carboxy methyl cellulose and carbopol 934. The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release, ex vivo mucoadhesion time and ex vivo drug permeation. Tablets containing sodium alginate as a polymer (F2) had the maximum percentage of in vitro drug release. The surface pH of all tablets was found to be satisfactory (between 6.5 and 7.43), close to neutral pH; hence buccal cavity irritation should not occur with these tablets. F2 batch was considered optimum based on good bioadhesive strength (02.60±0.03 gm) .The drug release from optimum batch followed zero order kinetics with Higuchi release. Drug excipients compatibility study showed no interaction between drug and excipients. Stability study of optimized formulation showed that tablets were stable at accelerated environment condition. Thus, buccal adhesive tablet of Lesinurad could be an alternative route to bypass hepatic first pass metabolism and to improve bioavailability of Lesinurad.
