Objective: The aim in the present investigation was to design and evaluate the gastro retentive mucoadhesive delivery system of Zidovudine with a view to enhance the gastric residence time and its oral bioavailability.In the current work, direct compression method has been employed to prepare GRDDS of Zidovudine with HPMC K100M, NaCMC, Carbopol934P and PVP K30 with different drug to polymer ratios. Various evaluation tests and stability tests were conducted.Pre formulation studies for all formulations showed satisfactory results. FTIR studies evidenced that drugs and polymers were compatible. Followed by The formulated tablets were subjected for various evaluation parameters like hardness(3.98±0.654 to 3.09±0.455 kg/cm2), thickness(2.98 ±0.13-2.29 ±0.09 mm), weight variation(303.69 ±1.428-298.35 ±1.006 mg), drug content(100.65 ±0.45-97.81 ±0.590 mg),friability(0.75 ±0.04-0.45 ±0.07), results showed all extensively passed, all the evaluation tests as per USP standards. Swelling index, mucoadhesive strength, Ex-Vivo Residence Time results were propositional to concentration polymers. In dissolution study it was observed that release of Zidovudine from different formulations was spread over a period of 8-12hrs depending on the polymerâs concentration and viscosity. mong rio s orm l tions st died 1 ont ining 1 nd sho ed dr g rele se t the end o 12hrs nd o nd to e st le t C and 75% RH following a three month stability study.
