In the present work we studied Salvadora persica L. crud extracts of ethanol, acetone and water extracts of the leaves, stem bark and fruit peels on anti-inflammatory and anti-cancer activity in HeLa cell lines against by trypan blue dye exclusion method. Ethanol fraction of Salvadora persica leaf extract (300 mg/kg b.w. p.o.) has shown significantly high percentage of anticancer property as 69.1% of dead cells. Furthermore the effect of ethanol, acetone and water extracts of leaves, stem bark and fruit peels of Salvadora persica demonstrated that the anti-cancer activity in EAC cell inoculated swiss albino mice. Ethanol extracts of leaf, bark and fruit feels at 300 mg/kg b.w. p.o. dose shown significant prolongation of lifespan, reduction in tumor volume and improvement in the hematological parameters when compared to the other extracts of Salvodara persica. There by it can be concluded that ethanol extracts of leaf, bark and fruit peels possesses better anti-inflammatory and anticancer activity at 300 mg/kg b.w. p.o. dose than acetone and water extracts.