This review will highlight work done in our laboratories formulating and evaluating topical liposomal delivery is a mostly used both in vivo and in vitro methods by using animal models .The recent therapeutic work done on drug delivery using Topical Liposomes as carrier for small and large molecules. Topical Liposomes are solid colloidal particles in size from 10nm-1000nm. They are sphere shaped vesicles made up of one or more phospholipid bilayers. It shows greater affinity towards horny layer of skin and penetrates skin deeper tissues with more absorption rate. When topical liposomes are applied on the skin, they act as a solubilizing matrix for poorly soluble drugs and reduce the side effects of these drugs. Topical liposome formulations are more effective and less toxic than conventional formulations (Tablets, capsules etc.). They also alter and improve pharmacokinetic and pharmacodynamic properties of less efficacious drugs. This review discusses the potential advantages in topical drug delivery, mechanism of action, method of preparation, characterization and application of Topical Liposomes drug delivery system.
