We investigated the possible antihyperlipidemic activity of a hydroalchoholic extract of an herbal preparation from a combination of three Indian medicinal plants against Triton WR-1339 induced hyperlipidemia in male Wistar rats. The current study was undertaken to assess the hypolipidemic, hypocholestrolemic and hypotriglyceridemic potential of the Polyherbal Formulation (PHF) using Triton WR-1339 (Tyloxapol) induced hyperlipidemia. The male Wistar rats were divided into five groupsâ of six animals in each group normal control, hyperlipidemic control, hyperlipidemic plus polyherbal extract and hyperlipidemic plus Atorvastatin. Hyperlipidemia was induced in overnight fasted Wistar rats by single intravenous (IV) injection of 200 mg/kg or 2ml/kg of Triton WR-1339 in Normal Saline (0.9% NaCl) and it showed sustained elevated levels of serum Total Cholesterol (TC), Triglyceride (TG), LDL-C and VLDL. The Polyherbal Formulation (200 and 400 mg/kg/b.w. /p.o.) and Atorvastatin (10 mg/kg/b.w. /p.o.) was administered orally for seven days to Triton Wr-1339 induced hyperlipidemic rats. The PHF significantly decreased serum total cholesterol, triglyceride, LDL-C, VLDL, Atherogenic Index and increased HDL-C levels. Atherogenic Index and Triglyceride and cholesterol secretion rate were lowered in the polyherbal extract fed animals when compared to hyperlipidemic control animals. Polyherbal extract exhibited quite competitive potential when compared with the reference drug Atorvastatin affording a possible alternative natural therapeutic agent in the treatment of hyperlipidemia. The present work provides scientific evidence of therapeutic potential of hydroalchoholic extract of polyherbal formulation against hyperlipidemia. Hence, we suggest that the inclusion of this PHF in the management of hypercholesterolemia and hypertriglyceridemia.
