An effort was taken to prepare and evaluate 18? glycyrrhetinic acid transdermal patch for anti smoking activity. 18? glycyrrhetinic acid was obtained from the herb liquorice. The transdermal patches were prepared using solvent casting technique. Eight formulations were prepared with 400mg of drug along with polymers like ethyl cellulose and hydroxyl propyl methyl cellulose. Evaluation parameters like weight, thickness, percentage moisture uptake, folding endurance water vapour transmission rate, in-vitro release were studied for eight formulations. The formulation F1 showed a good release profile due to increase in concentration of penetration enhancer. The in-vitro study showed that 18? glycyrrhetinic acid would be a potential drug delivery system for its anti-smoking potential. The in-vivo studies also showed that the probability of TDDS of 18-?-glycyrrhetinic acid in sufficient amount into the systemic circulation which would be a potential drug delivery system for its anti-smoking potential. From this study it has concluded that 18-? glycyrrhetinic acid can be used for antismoking activity due to its improved penetration in blood circulation.
