Abstract

Considering that oxidative stress is strongly implicated in the toxicity of chemotherapy, much effort is focused on the research of diverse antioxidants as protective agents. Benzophenone and its derivatives play an important role in medicinal field with many pharmacological activities. An efficient synthesis and antimicrobial efficacy of novel benzophenones containing 3-(2-aroylaryloxy) methyl-6-phenyl-1,2,4-triazolo[3,4-b][1,3,4] thiadiazine 6a-e is described previously. Further to ensure antioxidant properties of compounds 6a-e we have subjected all the compounds to DPPH, nitric oxide and hydrogen peroxide scavenging assay. Compounds 6b, 6e and 6d were showed potent antioxidant activity near to standard ascorbic acid due to the presence of chloro, methoxy and methyl substituent’s respectively and remaining analogues in the series shown moderate to poor potency.