The functions of human body vary considerably in a day. These are due to the circadian clock of human body and can also be stated as the circadian rhythms. Depending on the variations in the circadian clock the disease patterns and its effect on the body also varies in a day. Now Chronotherapy is a new concept in the Novel Drug Delivery System [NDDS]. Chronotherapy is nothing but the treatment of many disorders or ailments like asthma, cardio-vascular disorders, hypertension, arthritis etc., by relating the drug pharmacokinetics with the changes in the biological rhythms of the human body. This principle can be achieved by the timely release of the active substance into the systemic circulation when the therapeutic effects can be maximized. The various approaches for this also have been discussed below. In this review, the concepts of biological rhythms and chronotherapy have been discussed. The very purpose of chronotherapy is to increase the efficiency of the drug molecule against the disorder and reduce the side-effects of the therapy.

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