Abstract

Matrix type of ocular insert was prepared using hydrophilic polymer PVP
K 30 in different concentration by solvent casting method. The
compatibility study of drug and polymer was performed by FTIR and DSC
study and results revealed that drug and polymer are compatible to each
other. Physicochemical evaluations like weight variation, thickness,
content uniformity, moisture absorption, moisture loss test were
performed. In vitro release study was carried out for all formulations and
overall results revealed that as concentration of polymer increases there
was slow release of Dorsolamide HCl occurred from the formulation.