Clitoria ternatea root is widely used in neuralgia for traditional and herbal medicine. In this study we evaluate the therapeutic strategies to accelerate the reconstruction of lost myelin sheath. The Methanolic root extract of Clitoria ternatea was tested at 100mg/kg and 200mg/kg when administered orally for a period of 28 days after induction demyelination in wistar rats by giving intra cranial injection of ethidium bromide at a dose of 1?g/0.03ml of PBS/kg body weight. The efficacy was expressed in terms of behavioural studies were observed on 1st, 2nd and 4th week. After 28 days the animals were sacrificed and brain tissue was subjected to histopathological and biochemical studies. The result from behavioural, histopathological and biochemical studies suggested that the Methanolic extract of Clitoria ternatea root have potential protective effect on the ethidium bromide induced demyelination on wistar rats by intra cranial administration. In the pharmacological evaluation of methanolic extract of Clitoria ternatea root for their protective effect on demyelinated motor neuron diseases.