Abstract
The methanol extract of Allium hookerii leaves was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes was induced in Wistar Albino rats by administration of single dose of Streptozotocin (70mg/kg). The methanol extract of Allium hookerii at the dose of 150mg/kg and 300mg/kg, p.o. was administered as single dose per day to diabetes induced rats for a period of 21 days. The effect of Allium hookerii extract on body weight of the animals, blood glucose, serum lipid profile [cholesterol, triglycerides], serum enzymes [serum glutamate oxaloacetate transamines (SGOT), Serum glutamate pyruvate transaminases (SGPT), SALP, total protein were measured in the diabetic rats. Allium hookerii extract elicited significant (p< 0.01) reductions of blood glucose, lipid parameters and serum enzymes and significant (p<0.01) reductions of blood glucose. From the above result, it is concluded that methanolic extract of Allium hookerii leaf extract possesses significant anti-diabetic effects in Streptozotocin induced diabetic rats.
