Abstract
Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. The era of nanotechnology has revolutionized the drug delivery system and persuades new research strategies to flourish. SLN have attracted various research groups and companies since the early 1990s, however research in the SLNs is still in its infancy. SLN technology based therapy has made available a novel and sound platform for therapeutics. They have been developed as an important strategy to deliver drugs by modifying their release, body distribution and kinetics of associated along with tissue and cell targeting of drugs and reduction of unwanted side effects by controlled release of the medicament. They are interesting vectors for oral delivery of lipophilic and to a certain extent, hydrophilic substances. The presence of lipids in the absorption process or transfer of hydrophilic molecules to more lipophilic molecules by conjugation has been reported to increase the oral absorption. The lipid absorption enhancing effect can even be more pronounced when combining lipid technology with nanotechnology, which is creating lipidic solid nanoparticles.
