Abstract
The present investigations deals with the formulation of fast dissolving tablet of Meloxicam with the effect of different Novel co-processed superdisintegrants by solvent evaporation method that disintegrate in oral cavity on contact with saliva & thereby improve therapeutic efficacy. Over the past three decades, mouth dissolving or orally disintegrating tablets have gained considerable attention as a preferred alternative to conventional tablets due to better patient compliance. Meloxicam is a newer selective cox-1 inhibitor & the present research shows that the use of different co-processed superdisintegrants enhance the activity of meloxicam through rapid release. The tablet containing drug were prepared by direct compression methods using Novel co-processed superdisintegrants as Starlac, Ludipress, Ran explo-S, Ran explo-C, Pan-excea MH-300G. The tablets were evaluated for thickness, weight variation test, drug content, hardness, friability and in-vitro drug release studies. In-vitro drug release studies of the prepared tablets were conducted for a period of 25 minutes using an USP dissolution test apparatus (type II Paddle) at 37±0.5°C and 75 rpm. The optimized formulation-F8 containing Ran explo-S showed 99.15 % drug release in 25minutes. The tablets prepared from Co-processed superdisintegrants shows optimum result as compared to other superdisintegrants if use alone. Thus result shows that Co-processing of superdisintegrants is most suitable approach for formulation of Fast dissolving tablet.
