The term psychosis is very broad and can mean anything from relatively normal aberrant experiences to the complex and catatonic expressions of schizophrenia and bipolar type-1 disorder1. Many targets for the treatment of psychosis are available namely NMDA receptor antagonists, Ketamine and MK-801, peptide deformylase, Acetylcholinesterase, G protein-coupled receptors, glutamate synthase (NADPH). The Protein-Ligand interactions plays a significant role in structural steroid hormones glutamate synthase (NADPH) Acetylcholinesterase, G protein-coupled receptors, transforming based drug designing. In our Present research work we have chosen glutamate synthase2 (NADPH) and Acetylcholinesterase3 as targets to screen our proposed chemical structures for anti-psychotropic activity. The molecules were docked to the above said targets and the energy values obtained are as follows using the docking software. Depending on the energy values we have chosen the best two drug analogs they are Compound 3e {-9.4}, Compound 3k {-10.0}. We tried to improve the binding efficiency and steric compatibility. Several modifications were made to the probable functional groups which are interacting with receptor molecules. Analogs of this drug molecule were prepared using ACD-chem.-sketch and docking. The modified drugs was sketched using chem.-sketch were found to be better than the conventional drugs available.
