Abstract

Linagliptin is an oral anti-diabetic drug belong to the class of dipeptidyl peptidase -4 (DPP-4 inhibitors).It is widely used in the treatment of type –II diabetes mellitus which is characterized by insulin resistance in pheripheral tissue and insulin secretory defect of the β – cells.Linagliptin is been approved by the US food & Drug administration for the management of type –II diabetes. This work aims to compiling the published analytical methods referred so far in the literature in the determination of linagliptin in the biological samples and pharmaceutical formulations. Techniques like HPLC, UV & MASS spectroscopy, EI – Tandem Mass spectrometry, pharmacokinetic studies & spectrophotometric methods have been utilized so far in the analysis, from which we can seen HPLC methods have been operated most extensively in various analytical perspectives. Based on the findings of the present review, linagliptin is widely used as an treatment adjunctive to a regimen of an insulin secretagogue.