Abstract
A simple UV spectrophotometric method has been developed for the simultaneous analysis of Amlodipine and Clopidogrel in tablet dosage form is based on the absorbance ratio method. The acidic methanol was used as solvent. The two wavelengths were selected 239.4nm as isosbestic point and 361.8 nm as absorption maxima for Amlodipine for the analysis. Amlodipine and Clopidogrel obeyed Beer‐Lambert’s law in the concentration range of 1‐3μg/ml and 30‐90μg/ml with coefficient of correlation 0.9970 and 0.9960 at 239.4 nm respectively. Amlodipine was obeyed Beer‐Lambert’s law in the concentration range1‐3μg/ml with coefficient of correlation 0.999 at 361.8 nm. Recovery of the developed method was found to be in the range of 100.60% for CL and 100.7% for AM. This proposed method was statistically validated in accordance with ICH guidelines. This method was found to be accurate, precise and rugged as indicated by low values (<2%) of % RSD. This method was also found to be rapid and economical can successfully be applied for the routine analysis of bulk and combined tablet dosage form.
