Abstract
Fairly soluble drugs in gastrointestinal (GI) media exhibit complete oral absorption, and thus good bioavailability. About 40% of drugs are not soluble in water in practice and therefore are slowly absorbed, which results in insufficient and uneven bioavailability and GI toxicity. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancement of drug solubility and thereby itâs oral bioavailability. The objective of present work was to improve solubility and dissolution rate of poorly water soluble drug Simvastatin by Microwave Generated bionanocomposites technique. The nanocomposites prepared using natural polymers (Gum Ghatti, Guar Gum and Gum Acacia) enhances solubility and dissolution rate of drug. Nanocomposites prepared are characterized by DSC, SEM, and XRD which indicates that crystallinity of Simvastatin has been reduced significantly. Solubility study result helped for selection of gum and gave best ratio of drug and polymer. In vitro drug release from prepared immediate release tablet was compared with marketed formulation. Accelerated stability study of optimized batch was performed at C/75% RH and the results suggested that the formulation was stable for three months. Therefore, microwave generated nanocomposites using natural polymer could be successful technique for enhancing the solubility of poorly water soluble Simvastatin. It should be concluded, that the natural polymers having surfactant activity that enhances the solubility and dissolution rate of drug. The optimum ratio of drug to modified natural polymer was found to be 1:3 w/w. This shows higher dissolution as compared to marketed tablet. The selected SDâs showed better anti-cholesterol and anti-lipidimic activity compared to plain drug.
