Abstract
Atorvastatin calcium is a lipid lowering drug which acts by inhibiting the HMG-CoA reductase enzyme thereby resulting in reduced cholesterol synthesis. It comes under class- II for the BCS system. The present investigation was undertaken to enhance dissolution by formulating ODT of ATC using natural super disintegrant banana powder. βcyclodextrin inclusion complex with drug was prepared by kneading method in different ratios of drug and carrier. βcyclodextrin inclusion complex prepared at molar ratio of 1:3 showed high solubility .So 1:3 ratio of β cyclodextrin complex was selected for the preparation of ODT. To increase the dissolution the tablets were formulated using natural super disintegrant banana powder by direct compression method and evaluated for hardness, disintegration, friability, in-vitro drug release. The optimized formulation with β cyclodextrin inclusion complex containing 3% of banana powder showed less disintegration time i.e. 26 seconds and increased drug release. Stability study of optimized formulation was conducted for a period of 3 months. ODT were also prepared with synthetic disintegrant (SSG, MCC) and the dissolution studies were compared.
