Abstract
A simple, rapid, precise and accurate Rp-Hplc method was developed and validated for the determination of Ixazomib citrate, in bulk and pharmaceutical dosage form. The separation is achieved on RP-HPLC using a PDA detector by incorporation of enpower 2 software with a flow rate of 1.0ml/min using a mixture of Methanol and water (15:85% v/v) as mobile phase. The column used was Hypersil C18 (4.6×150mm, 5μ) at a wave length of 284nm. The retention time of the Ixazomib citrate was 3.515min. The linearity of the drug was 25-125μg/m and the method precision for the determination of assay was below 2.0%RSD. The proposed method was validated and applied for the estimation of ixazomib citrate in quality control of bulk and pharmaceutical dosage forms.
