Abstract

OBJECTIVE The present study was to evaluate the antihyperlipidemic activity for methanolic extract of Nyctanthes arbor-tristis (Linn.) leaves. METHADOLOGY Methanolic extract of Nyctathes arbor-tristis (MENA) was evaluated for in vitro antioxidant assay by reducing power assay and hydrogen peroxide assay and in vivo models of antihyperlipidemic study was carried out by three methods those are cholesterol diet, triton 100 X and fructose. The serum was collected and analyzed for lipid profile total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein. RESULTS Methanolic extract of Nyctanthes arbor-tristis leaves at the doses of 200 and 400 mg/kg bd. wt showed significance (p < 0.01) decrease in lipid profile like TC, TG, LDL, VLDL and showed significance (p < 0.01) increase in HDL. CONCLUSION MENA showed significant antihyperlipidemic activity with specific and non-specific mechanism which may be due to the presence of phytochemical constituents like phenols, triterpenoids and flavonoids.