Abstract
Cognitive impairment is a common problem in people more than 65-year age group, progressing to Alzheimer’s disease. Pathophysiology of many neurological, particularly neurodegenerative diseases shows presence of oxidative stress. Objective of the research was to investigate the antioxidant potential of Kinnow fruit juice in Scopolamine induced cognitive impaired albino rats. Kinnow fruit juice contain phytochemical constituents such as Vitamin C and Flavanoids. 07 groups of Albino rats were randomized for study on morris water maze. Kinnow fruit juice was administered orally in four doses (2.5, 05, 7.5 & 10% v/v, p.o.), once daily for 30 days in different groups. Albino wistar rats treated with single intraperitoneal injection of Scopolamine (01 mg/kg body weight) for induction of amnesia. Effect of Kinnow fruit juice on oxidative markers (MDA, GSH & SOD) level was assessed in the brain tissue of albino rats. Scopolamine treated albino rats showed significant increase in escape latency time (impairment in acquisition) and significant decrease in Time spent in target quadrant (impairment in retention) in morris water maze. Pre treatments with Kinnow fruit juice showed significant decrease in escape latency time and significant increase in Time spent in target quadrant indicated protection from scopolamine induced amnesia and improvement of memory. Treatment with Kinnow fruit juice significantly inhibited the Scopolamine induced rise in brain MDA, decrease in GSH & SOD level. Memory enhancement may be linked to antioxidant potential of Kinnow fruit juice. These results suggest that Kinnow fruit juice have a potential role in the management of cognitive dysfunctions.
