Abstract

The objective of the present research study is to develop compression coated tablets of piroxicam with a view of minimizing the drug release in the physiological environment of stomach and small intestine and to achieve maximum drug release in the physiological environment of colon by applying applying polymers like microcrystalline cellulose (MCC), sodium starch glycollate (SSG), guar gum/hydroxypropylmethylcellulose (HPMC), sodium lauryl sulphate (SLS), talc and magnesium stearate piraxicam core tablets. The prepared tablets were evaluated for their pre and post compression parameters. In vitro drug release studies were conducted in pH1.2 buffer, phosphate buffer (pH7.4). A significant difference was observed in the amount of piroxicam released at the end of 24hr of the dissolution study.