Abstract
Several high value added therapeutic biomolecules and their precursors exist in nature but yet to be discovered to fight against severe deadly diseases. Rapid emergence of drug resistance phenomena creates additional alarming situation and driving force to alleviate novel drug discoveries as earliest. Microscopic bugs, animals, and medicinal plants are the major source of novel therapeutic biomolecules generations following extraction, characterization, screening, and large scale production. However, conventional methodologies have not yet been shown great efficacy to generate novel drugs as far economical and industrial standpoints. To this end, the current review has shown a promising route that is combinatorial approach of synthetic biology and metabolic engineering for novel drug discovery. Though synthetic microbial metabolism is in its infancy but holds an enormous potential to battle against antibiotic resistance via providing high value added therapeutic biomolecules in near future. In conclusion, synthetic biology and metabolic engineering could be a potential avenue for novel drugs generations.
