Abstract
In the course of recent decade, extensive research has been carried out to develop a gastroretentive dosage form (GDF). This sort of dosage form can enhance the delivery and execution of drugs that are locally active in the stomach, in light of the fact that the GDF allows the drug to stay in the stomach for an adequate time interim. Distinctive methodologies have been used to develop the efficient GDFs such as low density systems, high density systems, super-porous hydrogels, hydrodynamically balanced systems, gas generating systems, super-porous hydrogels raft forming systems, swelling and expanding systems, floating systems, and ion exchange resins. However, these kinds of systems possess both advantages and disadvantages. Intra-individual and inter-individual differences in gastric physiology are impediments in the development of efficient GDFs. Examples of these individual differences include gastric pH and gastric motility, which have a significant impact on gastric retention time and drug delivery. Some of these hindrances can be overcome by building up a novel mucoadhesive floating drug delivery system (MFDDS). The MFDDS is characterized by intimate contact of the mucoadhesive dosage form with the mucosal layer, thereby increasing the localized absorption of the drug.
