Abstract
Cancer is a potentially major disease caused mainly by many surrounding factors that mutate genes encoding critical cell-regulatory proteins. The resultant aberrant cell behaviour leads to expansive masses of abnormal cells that destroy surrounding normal tissue and can spread to vital organs resulting in disseminated disease, commonly patient death is occurred. Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through various methods which are explained in this review. The effect of substitution at the 2- and 4-positions was investigated. Thiazole is also showing various biological activities but recently it shows major activity as anticancer with minimizing side effect and adverse effect. It also has large area for research with same biological activity.
