Abstract
Loratadine is a anti allergic drug (NSAID) used in the management of the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticarial (hives), chronic idiopathic urticaria. Loratadine is a poorly water-soluble drug and for such drugs, dissolution plays an important role in their absorption. In the present investigation, an approach of solvent deposited systems of the dispersions of loratadine in Gelucire – 50/13 (G) and Hydroxypropyl cellulose (HPC) on Neusilin (N) were prepared to enhance the dissolution of loratadine. Dispersions were prepared employing different proportions of the carriers. The prepared dispersions were characterized by infra-red spectroscopy, x – ray diffraction and differential scanning calorimetry. The results of the XRD and DSC study indicated that the drug existed in amorphous form in the dispersions. The dispersions exhibited higher dissolution compared to the pure drug and there were no interactions with the carriers. Dispersion in gelucire showed much higher dissolution than the dispersion in hydroxypropyl cellulose. There was 10 to 12 fold increase in dissolution rate with various dispersions when compared with the pure drug. Dispersions on neusilin resulted in products which had good flow properties enabling direct compression of the dispersion into tablets. The Kawakita constants calculated for the various products are suggestive of good flow character. All the tablets showed good pharmaceutical characteristics and exhibited rapid dissolution. From the results of the investigation in may be concluded that employing solvent deposited systems of the solid dispersions is a useful approach to prepare the fast dissolving tablets of loratadine.
