Abstract
In the present study, a novel series of N-acetyl pyrazolines (4a-j) were synthesized from different chalcones (3a-j) with hydrazine hydrate and glacial acetic acid. The compounds were synthesized and characterizes by TLC, melting points, IR, and 1H-NMR spectra. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve, Bacillus subtilis gr +ve, Salmonella typhi gr –ve , and antifungal activity against Aspergillus oryzoe, Aspergillus niger, using disc diffusion method. The compounds show the moderate to good activity against bacteria. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.
