Abstract
The purpose of the present study was to formulate the solid self-emulsifying drug delivery system by using Cinnamon oil, Cremephore RH 40, PEG 600, Ethanol as oil phase, surfactant, co-surfactant, and co-solvent of poorly water soluble (BCS Class II type) drug ketoprofen. Aerosil 200 was used as an adsorbing agent and convert liquid form to solid form and develop S-SEDDS by adsorption to solid carrier technique. The main objective of study was to prepared S-SEDDS of ketoprofen on the basis of preformulation study like solubility study, pseudo ternary phase diagram, standard curve preparation and FTIR study in order to achieve a better dissolution rate which would further help in enhancing absorption and oral bioavailability. The solubility of Ketoprofen was determined in several oils, surfactants and co-surfactants using an UV method. For stable SEDDS, micro-emulsion region was identified by constructing pseudo ternary phase diagram containing different portion of surfactant: co-surfactant (1:1, 2:1, 3:1), oil and water. Four Solid and Liquid SEDDS were prepared by selecting different proportions from self-micro emulsifying region and evaluated for their self-dispersibility, thermodynamic stability of emulsion, micromeritic property, drug content, in-vitro drug release study. The formulation was found to show a significant improvement in the drug release from powered drug ketoprofen. Drug release from S-SEDDS (F3) is 98.1536 % in 6 hrs. and the conventional release self-emulsifying formulations followed first order release kinetics model.
