Abstract
We applied simple and convenient procedure for the synthesis of optically active1,5- benzothiazepine derivatives by reaction of 2-aminothiophenol with newly synthesized Chalcones under mild conditions in the presence of catalytic amount of Lanthanum Nitrate in short reaction time with excellent yield(75-85%). The compounds (4a-l) were tested for purity by TLC and characterized by M.P, IR and 1H NMR and Mass spectral studies. The synthesized compounds have been screened for antibacterial activity against Staphylococcus aureus gram +ve, Escherichia coli gram –ve Bacillus subtilis gram +ve, Salmonella typhi gram –ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger, using disc diffusion method. The compounds show the moderate to good activity against bacteria and fungui.
