ABSTRACT
It is well established that the active ingredient in a solid dosage form must undergo dissolution before it is available for absorption from the GIT. About 40 % of the newly discovered drugs fall into poorly water soluble or water insoluble categories. The aqueous solubility for poorly water soluble drugs is usually less than 100 µg/ml. Liquisolid compact system is a novel concept of drug delivery that can change the dissolution rate of water insoluble drugs. Formulation and manufacture of the Liquisolid compacts is quite simple method according to new mathematical model described by Spireas et al. The technique is based up on dissolving the insoluble drug in the non-volatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution, or in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Liquisolid system is characterized by flow behaviour, saturation solubility, drug content, Fourier transform infra red spectroscopy, in-vitro release, release kinetics and stability studies.
