Abstract
The objective of the present study was to incorporate poorly soluble Aceclofenac (ACF)
into microemulsion based formulation. In present study microemulsion was prepared with
6% w/w Isopropyl Myristate (IPM), 27%w/w Tween 80 & 18%w/w PEG-400 as oil,
surfactant & Cosurfactant respectively. The ratio of surfactant: cosurfactant was fixed at
4:1 on the basis of Ternary phase diagram. Microemulsion gel was prepared using 1%
Carbopol 934 as a gelling agent. Optimized formulation was evaluated for drug content,
zeta potential, droplet size, drug assay, pH, viscosity, in-vitro drug release profile and
stability study. Globule size of optimize batch ACF 5 was found to be 11.52 ± 0.6 nm. In
vitro release study had shown 25.55 ± 2.39 % drug release from microemulsion gel which
was more compared to marketed product. Optimize batch ACF 5 was found stable
throughout stability study for two months at different temperature (2-8°c & room
temperature).
