Abstract

BACKGROUND As drug use evaluation helps the healthcare system to understand, interpret and improve the prescribing, administration and use of medication, the study helps to evaluate the rational use of drug therapy in Aminoglycosides METHODS The study design was prospective and concurrent Drug Utilization Evaluation (DUE) study between February 1, 2015 to October 30, 2015. The study included all patients who received Aminoglycosides during nine months period, which consist of phase I (without intervention for 4 months), and phase II with an educational intervention in the intervening period of next 5 months. The DUE criteria and guidelines for all the drugs included in the study were prepared from standard references and utilized for monitoring the patients based on indication for use, dose, dosage form, duration of therapy, side effects, laboratory testing and drug interaction. The drug use guidelines prepared for selected drugs included in the study and circulated to all medical staff of various departments in hospital. In the study justification of drug use, process indicators and outcome indicators were evaluated. RESULTS The results of the study shown that there was increase in inappropriate indication, inappropriate dosing, drug-drug interaction and adverse drug reaction in Phase I (Before intervention) for the drugs included in the study, where as in Phase II (After intervention) a period of 5 months, study results shown decrease in inappropriateness of drug use for indication, dosing, for the drugs included in study compared to Phase I. Adverse drug reaction and Drug-Drug interactions reduced due to implementation of DUE guidelines and through educational interventions.