Abstract
Fast dissolving tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva. Albendazole is anthalmentic agent which is used in disease like worms. As a vermicidal,albendazole causes degenerative alterations in the intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. It is a BCS class II drug. It exhibits poor bioavailability of about < 5% which is attributed to its poor solubility. The work was carried out to improve the solubility of albendazoleby direct compression technique and increasing its disintegration time by formulation of fast dissolving tablets by Direct Compression method, with various ratios of Cross povidone and guar gum, as superdisintegrants.Tablets Pre compression parameters e.g. Angle of repose, Bulk density, Tapped density, Carr’s compressibility index and Hauser’s ratio andpost compression parameters like drug content uniformity,hardness,wetting time,friability, Thickness, Disintegration time & In vitro dissolution are evaluated for each formulation and found satisfactory. The formulation of cross providone and guargum disintegrants in the concentration i.e. in F6 batch gives best results. Formulation F6 of guargum and crosspovidone superdisintegrants required minimum disintegration time, wetting timeas compared to formulations of crosspovidone, guargum. So it can be concluded that albendazole can be successfully complexed with sodium starch glycolate prepare fast disintegrating tablet and showed enhanced dissolution rate.
