Abstract

The main objective of this combination therapy is to develop a stable formulation of a NASAID drugs an immediate release layer of Acetaminophen and sustain release layer of Tramadol are combine to the bilayer and evaluate their pre-compression and post-compression parameters. A bilayer tablet comprises first layer formulated for instant release of the Acetaminophen from a dissolving tablet and a second layer formulated for sustain release Tramadol from a bilayer tablet. The formulation of the developed work was initiated with direct compression method for acetaminophen layer and Tramadol layer. In the formulation of immediate release Crosscarmulose sodium and Crospovidone were used as super disintegrate and was directly compressed. Lactose was used as diluents. Magnesium stearate used as lubricant. The compressed bilayer tablets were evaluated for weight variation, thickness, hardness, friability, drug content, and in-vitro drug release using USP dissolution apparatus type 2 (paddle). The optimized Formulation table of no F2 and F4 % of release was 97.12% and 96.80%. of drug release for bilayer Tablet of acetaminophen and Tramadol.