Abstract
The present study investigates the interaction between Boerhavia diffusa (Punarnava capsules) and Diclofenac sodium powder using chick embryo model for anti-inflammatory activity. Boerhavia diffusa (Nyctaginaceae) is one of the significant indigenous medicinal plant with a broad spectrum of therapeutic activity. The medicinal value of this herb has been reported for its anti-diabetic and diuretic properties. In different areas of the world, it has also been used for analgesic, anti-inflammatory, and carminative activities. The present study was aimed at evaluation of herb- drug interaction between Boerhavia diffusa and Diclofenac sodium for the anti-inflammatory activity using chick embryo model. The inflammation was induced by placing whatman filter paper disc on the chorio-allantoic membrane of an 8-day chick embryo. This model is comparatively cheap, requires little space to perform and only small quantities of the drugs are required. Concurrently no interaction study has been performed on this selected herb and drug.
