Abstract

Atomoxetine hydrochloride was formulated as sustained release tablet employing tamarind seed polysaccharide, Guar gum, PVP, magnesium stearate, micro crystalline cellulose the sustained release tablets were investigated. The Sustained release matrix tablets contain atomoxetine hydrochloride were developed using a different drug polymer concentration of tamarind seed polysaccharide, guar gum. The tablets were prepared by directly using micro crystalline cellulose. The formulation was optimized on the basis of acceptable tablet properties and in-vitro drug release. The resulting formulation produced robust tablets with optimum hardness, thickness consistent weight uniformity and low friability. All tablets but one exhibited gradual and near completion sustained release for atomoxetine hydrochloride and 98.6% and 97.5 released at the end of 12 hrs. The results of dissolution studies indicated that formulation F8, the most successful of the study. The results suggest that the developed sustained release tablets of atomoxetine hcl could perform better than conventional dosage forms, leading to improved efficacy and better patient compliance.