Abstract
Oxytocin (OT) possesses vasodilator and anti-inflammatory properties but these are controversial till now. To the best of the knowledge, the relevant data regarding to the haematology were scared. The research study was tried to investigate the chronic effects of low dose OT on haematological parameters by using a rodent model i.e. albino mice. Thirty six immature female albino mice, Mus musculus (weight 8±2g and age 10days) were divided into 2 groups as control (n=18) and treated (n=18). The treated and control groups were received intraperitonial (i.p.) dose of synthetic oxytocin (50mIU/5μl/g body weight) and physiological saline (5μl/g body weight) respectively for different intervals i.e. 30, 60 and 90 days. And hematological parameters including total count white blood cells (TC-WBC), total count red blood cells (TC-RBC) and haemoglobin% (Hb%) in blood as well as total bilirubin in serum were measured. The major observations of the research study were that, OT did not show much significant variations (P>0.05) in TC-WBC, TC-RBC, Hb% and total bilirubin as compared to control group. Finally the research study was concluded that, synthetic OT did not alter haematological parameters as well as total bilirubin in female albino mice at selected dose and duration apart from this a care must be taken on usage of higher dose.
