Abstract

Advanced-age is associated with significant changes in physiological functions, and absorption, distribution, metabolism and elimination of drugs. Aging is characterized by progressive impairment of functional capacities of all system organs, reduction in homeostatic mechanisms, and altered response to receptor stimulation.These age-related physiologic changes influence both pharmacokinetics and Pharmacodynamic of drugs in elderly patients. Pharmacokinetic and Pharmacodynamic changes as well as polypharmacy and co-morbidities may alter significantly the effect of pharmacological treatment with advancing age. With the same drug concentration at the site of action, significant differences in the response to several drugs have been observed in older patients as compared to younger patients. Therefore drug effects are mitigated less, the reactions are usually stronger than in younger subjects, and the rate and intensity of adverse effects are higher. The age-related changes in the functions and composition of the human body require adjustments of dosage for old individuals. If the normal doses of drugs is given to elderly patients, their response different form younger adults because of various physiological alterations and pharmacokinetic alterations of drugs. Main aim of this study we were drugs taken depends on physiological effects like drugs FUROSEMIDE, AMIKACIN, DIGOXIN Hence dosage adjustment is necessary in geriatric population for providing safe and effective management.