Abstract
The aim of this research work to formulate mouth dissolving tablets of memantine hydrochloride to increase its bioavailability. Mouth dissolving tablets were prepared by direct compression technique using sublimation approach. The powder mixtures were prepared to subject both pre and post compression evaluation parameters like micromeritics properties, tablet hardness, friability, wetting time, disintegration time and in vitro drug release. The results of micromeritics studies revealed that all formulations were of acceptable to good flowability. Tablet friability and hardness indicated good mechanical strength. The F2 formulation which is having high concentration of magnesium stearate was given promising results in tablet disintegration, waiting time and gives faster dissolution rate. Crospovidone was used as a superdisintegrant for increasing of dissolution rate of tablets. The optimized formulation showed 98.64% within 10 min. The prepared tablets seem to be attractive to conventional marketed formulations.
