Abstract
An in vitro release testing (IVRT) plays an important role in several area during the topical product development. This review article represents different IVRT techniques such as Franz diffusion cells method, Enhancer cells method, Flow through cell method and Parallel artificial membrane permeability assay (PAMPA) and their application in topical formulation development. It can be used as an in vitro surrogate for in vivo performance that can guide formulation development, sameness study for bio-waiver and ascertain the need for bioequivalence tests in generic topical formulations. PAMPA can be utilized for evaluation of drug retention factor, permeability parameters and permeability coefficients during product development.
