Abstract

A two series of quinazolinone derived Schiff base derivatives 7-28 were synthesized and characterized by analytical and spectoscopical methods. The in vitro antimicrobial activities of these compounds were evaluated and compared with antibacterial and antifungal standards chloroamphinicol and bavistin respectively. The most of the analogues shows good antimicrobial agents. Preliminary structure-activity relationship revealed that the compounds containing electron donating moiety (OH, OCH3) were found to be good antimicrobial activity where as compounds containing electron withdrawing moiety (Cl, NO2) were found to be least activity. Conclusion: Compounds containing electron donating moiety (OH, OCH3) were found to be good antimicrobial activity where as compounds containing electron withdrawing moiety (Cl, NO2) were found to be least activity.