Abstract
Two simple visible spectrophotometric methods (A and B) for the assay of Eletriptan hydrobromide, in pure and pharmaceutical formulations based on functional moieties (one or more) vulnerable to oxidation selectively with excess oxidizing agent CAT in Method-B, and the colour development of un reacted oxidant with the appropriate reagent or the reduced form of the reagent FC in Method-A under experimental conditions. The coloured products exhibit absorption λmax at 735nm,527nm;regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (4-24) μg/ml for(5-30) μg/ml; correlation co-efficients are 0.9989, 0.9946; Sandell’s sensitivities are 0.5706 x 10-3, 6.6371 x 10-4 ( mole cm-1); molar absorptivity values are 3.3840 x 105, 6.9823 x 105 (μg cm-2) for methods A and B respectively. The results are found satisfactory and reproducible. These methods can be applied successfully for the estimation of Eletriptan hydrobromide in the presence of other ingredients that are usually present in formulations. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost without the need for expensive instrumentation and reagents.
