Abstract
Gastro-retentive in situ gel forming system have provided a suitable way of providing the controlled drug delivery within stomach where an environment specific gel forming solution, on conversion to gel, floats on the surface of the gastric fluids (due to less density than gastric contents). In this technique, a solution of low viscosity is used which on coming in contact with the gastric fluids, undergo change in polymeric conformation viscous gel of density lower than the gastric fluids is produced. In the present research work Oral floating Insitu gel of Metoprolol Succinate was formulated using Sodium alginate, Chitosan, Gellan Gum, Carbapol 940 in different ratio. The optimized batch (sodium alginate 2% : Gellan Gum 1%) in the ratio 2:1 gave release release of the drug for 12 hours. Invivo study was performed by providing the formulation to rabbit and then X-ray were taken for the confirmation of formation of gel in stomach and floating of dosage form for 12 hrs. And it was found to be floating for 12 hrs. The optimized formulation was found to be stable for 6 Months in accelerated stability studies.
