Abstract

Aim & Objective: The beneficial role of statins in primary and secondary prevention of coronary heart disease as well as in dyslipidemia has resulted in their frequent use in clinical practice. Statins have proven to be the most efficacious drug therapy for attaining significant reductions in low-density lipoprotein (LDL) cholesterol levels, and their benefits could extend beyond their plasma LDL–lowering effect. Statins may also have a role to play in the regression of atheroma and may also reduce the risk of developing atrial fibrillation. They also have an increasing role in managing cardiovascular risk in patients with relatively normal levels of plasma cholesterol. Result: Although all statins share a common mechanism of action, they differ in terms of their chemical structures, pharmacokinetic profiles, and lipid-modifying efficacy. Statin shows some adverse drug effects like mylagia and rabdomylosis, when taken for a long period. By using statin, cardiovascular disease and dyslipidemia can be improved .Conclusion: In future, study can be done on the basis of molecular and biochemical mechanisms of myopathy and rhabdomyolysis by statins as well as on Atherogenic Dyslipidemia.