Abstract
The Cuscuta reflexa contains flavonoids and tannins which may responsible for its CNS actions. The recent findings on Cuscuta reflexa have demonstrated its antioxidant, antiepileptic, anxiolytic and hepatoprotective. The present study involves the effect of ethanolic extract of Cuscuta reflexa (EECR) was investigated for memory enhancing activity by elevated plus maze (EPM) using Scopolamine induced amnesic rats. EECR was administered orally with a dose of 200mg/kg, once a daily, for 14 consecutive days, where Piracetam (200mg/kg p.o), Nootropic was administered to the rats as a standard drug. Scopolamine (1mg/kg i.p) was administered on 14th day to rats to induce dementia and biochemical estimations were performed such as Acetylcholinesterase(AChE), Superoxide dismutase (SOD), Reduced glutathione (GSH), Lipid peroxidation (LPO) and Histopathological study. The transfer latency (TL) was observed in scopolamine induced rats using EPM, which showed significant increase in TL (p<0.001) in acquisition and retrieval phases as compared to normal control group. The Scopolamine induced rats showed significant increase in p<0.0001 AChE and LPO as compared to normal control, where as in EECR treated rats showed p<0.0001 decrease in AChE and LPO and increase in p<0.0001 SOD and GSH.
