Abstract

The new tetralone esters 3-ethylcarboxy-4-chloro phenyl-6, 7-dimethoxy-1-tetarlone 9a, 3-ethyl carboxy-4-fluoro phenyl-6, 7-dimethoxy-1-tetarlone 9b and 3-ethyl carboxy-4-nitro phenyl-6, 7-dimethoxy-1-tetarlone 9c intermediates were synthesized in good yields by chalcone route for -apopicropodophyllin 2 analogues. The new molecules were characterized by spectral and elemental analysis data. The synthesized analogues were evaluated for anti-mitotic activity by onion root tip model showed strong to moderate activities compared with control. The molecules 9b and 9c showed good inhibition while the molecule 9a exhibited moderate activity.