Abstract

The synthesis of 7-O substituted Isoflavanone [3-(4’-methoxyphenyl)-4H-chromen-4-ones] was crried out by treating p-methoxyphenylacetic acid and resorcinol in the presence of anhydrous zinc chloride and phosphorous oxychloride to yield 1-(2,4-dihydroxyphenyl)-2-(4’-methoxyphenyl)ethanone. 1-(2,4-dihydroxyphenyl)-2-(4’-methoxyphenyl)ethanone is then treated with N,N’-dimethyl(chloromethylene) ammonium chloride to yield 7-hyroxy-3-(4’-methoxyphenyl)-4H-chromen-4-one. The resulting compound on subsequent addition with acid chlorides yields the title compounds. The structure of the newly synthesized compounds was established on the basis of physiochemical analysis and spectral analysis such as IR, H1-NMR and Mass Spectral data. The synthesized derivatives are evaluated for their anti-microbial, anti-inflammatory and anticancer activity.