Abstract
Natural medicine from a plant origin is still used as therapeutic agents especially for treating bacterial, fungal, viral, protozoal, helementic infections etc… Cassia alata is one of the best medicinal plant used for treating number of ailments from ancient days. As the anti fungal activity of ethanolic extract of Cassia alata leaves extract was already proved now we are formulating a topical herbal gel for treating the different types of microbial infections. We formulated a topical herbal gel with carbopol 940 and other excipients by adding 0.1%, 0.2% & 0.3% Cassia alata leaf extract. Both the stability and evaluation studies along with the skin irritation studies and in-vitro antimicrobial studies were performed to the prepared three formulations on 0 day, 15th day and on 30th day. All the herbal gel formulations shown pH- 6.8 and all the remaining physical parameters are shown good results in all the evaluated three days. Antimicrobial activity of the three formulations was tested by using isolated E coli. The Cassia alata herbal gel formulations shows potent antimicrobial activity in the exponential manner i.e 0.87±0.3, 1.18±0.1 & 1.83±0.4 cm for F1, F2 & F3 formulations respectively. Finally the formulation F3 shows the better antibacterial activity than the remaining two formulations and standard drug streptomycin and all the formulations are considered to be safe and stable. Anti fungal activity for these formulations is not yet performed the report will be published as early as possible. By the results it was clear that the Cassia alata Topical herbal gels were safe, stable and good for treating the both fungal and bacterial infections.
