Abstract
The present study was intended to evaluate the anticancer property of the selected four seaweeds viz., Sargasssum wightii Greville ex J.Agardh, Padina tetrastromatica Hauck (Paeophyceae), Ulva faciata Delile (Chlorophyceae) and Gracillaria edulis (S.G.Gmelin) P.C. Silva (Rhodophyta) from south east coast of India. The cytotoxic activity was determined against human A 549 lung adenocarcinoma cancer cell lines and Vero (African green monkey kidney cells) non‐cancerous cell line using the MTT method. Cytotoxic activity of methanolic seaweeds extracts against human A549 lung adenocarcinoma and African Green Monkey Kidney (VERO) showed a dose and time-dependent inhibitory effect. IC50 was 12μg/mL, 18μg/mL, 118.98μg/mL and 222.78μg/mL was observed in the seaweeds methanolic extracts of U. faciata, S. wightii, G. edulis and P. tetrastromatica respectively. The methanolic extract of selected seaweeds exerted a significant antiproliferative effect on the A-549 cancer cell lines. Simultaneously, it is evident that the methanolic extracts of selected seaweeds exhibited a less-prominent antiproliferative activity on the Vero cell line. The less-prominent antiproliferative activity of the methanolic extracts of selected seaweeds on the Vero cell line elicits the use of the methanolic extracts of selected seaweeds as a chemopreventive agent in cancer therapy.
