Abstract

Herbal therapy has been the most convenient mode of drug applications since the time im- memorable to the people of present pharmaceutical and clinical arena. Traditional medicines that are derived from medicinal plants are used by about 60% of the world’s population. Based on preformulation studies of raw material, granules of polyherbal tablets were prepared.for trial batch (T1-T5) The powder blends was evaluated for tests such as Angle of Repose, Bulk density, Tapped density, Compressibility ratio, and hausner’s ratio before punching of tablet. (pre-compression). The polyherbal tablet is used in arthritis. Pain and inflammation of joint is reduced due to the mode of action of boswellic acid on LOX enzyme. The polyherbal tablet is effective in comparison to other NSAIDS. In the present study, the polyherbal tablets were prepared using 32 full factorial design containing two factors evaluated at three levels. Initially five trial batches incorporating various concentration of disintegrants and lubricant were formulated and evaluated. The best batch (T4) containing sod. CMC (9mg) and Mg. Stearate (3mg) was selected as a source of information for designing factorial batches. Two evaluated independent formulation variables included: - Factor A (sod. CMC 5, 7 & 9 mg) and Factor B (Mg. stearate: 3, 5 & 7 mg). The experimental trials were performed at all possible combinations. The two response parameters like disintegration time and hardness were determined using design expert version (8.5.0.1) software for the construction of polynomial equation. All the formulated batches were evaluated for pre and post-compression parameters. All the batches of ployherbal tablets were evaluated for pre-compression parameters such as bulk density (0.649-0.688 gm/ml), tap density (0.686- 0.736 gm/cc), hausner’s ratio (1.05-1.13 ), angle of repose ( 25.43-28.630, carr’s index ( 5.23-11.8 ) & post-compression parameters like hardness ( 4.0 – 8.0 Kg/cm2), thickness ( 4.64-4.72), weight variation (510±5%), disintegration time ( 25-65 min) and friability (0.455-0.533) The results of accelerated stability studies revealed no physical and chemical changes in the tablets during three months of experiments. The finally optimized batch of formulation (D8) was subjected to check disintegration time and hardness. The actual response values were in accordance with the predicted values which showed validity of the model. The optimized formulation was subjected to stability studies which revealed the dosage form as stable with decreased D.T. time and optimum hardness.